search for a gene or a disease

Enter a gene or disease to explore the interactions between genes and diseases related to autism.

Update: We've made significant changes to the way disese-related gene sets are calculated on Autworks. Only gene-disease associations for which strong, recent evidence exists are now presented on the site. Additionally we made updates to our user-authenication infrastucture. As a result of this, users will have to re-upload any personal gene sets they want to analyze with Autworks. We would love to hear your feedback on these changes; don't hesitate to contact us

About These Tools

We are combining the power of network thinking with cross-disease analysis to generate a clear and clinically actionable genetic map for autism. We use human disease information from the National Institutes of Health and numerous trusted resources that report genes-to-disease and gene-to-gene associations in order to build and find both common genetic signals as well as signals unique to autism alone. We then test whether these signals can be used to improve diagnosis early, and enable faster delivery of behavioral therapies for newly diagnosed children with autism. A more detailed description of our methods may be found here.

Disease_network

Diseases

Within Autworks we have built a way to not only see which genes have been linked to autism, but to see how those genes interact with one another. Our hope is that by investigating the autism network -- the complete set of interactions among all known autism genes -- we will be able to find those gene combinations that cause the disorder, and pave the way towards faster diagnosis and treatment. Additionaly, we provide a list of specific variants linked to particular diseases with literature references.
Gene_network

Genes

Autworks contains detailed information on genes linked to autism and other human diseases. We provide an index of variants linked to disease in humans, allowing researchers to rapidly find references to causes of known mutations in the literature.
Create_gene_set

Hypothesis Testing

Autworks gives you the ability to create your own gene sets within the application for comparison against the corpus of gene and disease information within Autworks. Using this tool you can quickly measure the overlap between the genes you've identified with genes for every other disease in Autworks. Additionally, this feature allows you to observe the interactions between genes in your set and visualize the overlap between your set and other sets in Autworks.

Wall Lab Blog

Our Lab

The Wall Lab is in the Center for Biomedical Informatics at Harvard Medical School, on the fourth floor of the Countway Medical Library. We are translational bioinformaticians working on strategies to understand, diagnose, and treat complex human diseases, chiefly including autism.

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Contribute

Grasping the genetic complexity of autism is a monumental effort that will require unprecendented amounts of information. We are in the process of raising funds to gather this information. If you are interested in learning more about how to contribute to our mission, please contact us.
Designed by Kris S.

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